Explore ITCC-P4's paediatric PDX model repertoire

During the ITCC-P4 project term (2017-2023, more information can be found here), a large collection of patient derived xenograft (PDX) models across all relevant tumour entities, including high-risk, relapsed, and rare cancers, well representing the paediatric cancer landscape has been built. The models have been well chracterised including RNA & DNA sequencing as well as methylation profiling and in vivo treatment with standard-of-care drugs (+/- irradiation) and experimental drugs as well as combinations thereof. The data generated has been consolidated in the ITCC-P4 database which is implemented on the R2 platform, a versatile online tool operated by Amsterdam UMC. 

A subset of ITCC-P4’s paediatric PDX’s characterisation data is now available for the public at https://itccp4.com/database. Explore ITCC-P4's paediatric PDX model repertoire, get in touch and share your ideas with our experts! We help you select relevant models and elaborate the most suitable preclinical study design.